Research & Evidence
Every recommendation is backed by science.
Our framework is built on 100+ peer-reviewed studies spanning epigenetics, biomarker science, and longevity interventions.
45+ papers
Epigenetic Aging
DNA methylation clocks, DunedinPACE development, and biological age prediction models.
Key Findings
- Epigenetic age acceleration predicts mortality independent of chronological age
- Lifestyle interventions can reverse epigenetic aging by 1-3 years in 8 weeks
- DunedinPACE captures the pace of aging with higher sensitivity than static clocks
30+ papers
Biomarker Science
Blood biomarker panels, organ-specific aging markers, and metabolic health indicators.
Key Findings
- Multi-biomarker panels predict 10-year mortality better than single markers
- Organ-specific aging rates vary significantly within individuals
- Metabolic biomarkers respond to intervention within 3-6 months
35+ papers
Longevity Interventions
Evidence-based protocols for sleep, nutrition, exercise, stress, and the other 11 pillars.
Key Findings
- Sleep optimization alone can reduce biological age by 1-2 years
- Mediterranean diet patterns show consistent epigenetic age reversal
- Social connection is as impactful as smoking cessation for longevity